ABSTRACT
We evaluated the effect of gosyajinkigan in 30 cases of anticholinergic agent or α-1 blockers resistant nocturia with a sign of jinkyo which is the hypofunction of the kidney organ unit at Kampo medicine. As to subjective outcomes, storage symptoms and quality of life (QOL) of International Prostate Symptom Score, and sleep and energy items of King's Health Questionnaire and Nocturia QOL Questionnaire were statistically much improved. Concerning objective outcomes, nocturnal frequency of urination, nocturnal polyuria index and hours of undisturbed sleep by means of frequency volume chart, and total body water by body composition analyser were also statistically much improved. This study might demonstrate that normalization of body composition leads to reduce nocturnal urinary volume and improve nocturia.
ABSTRACT
We evaluated the effect of hachimijiogan in 30 cases of anticholinergic agent and α-blocker resistant LUTS. International Prostate Symptom Scores (IPSS), QOL scores, Benign Prostatic Hyperplasia Impact Index (BII) scores and urinary 8-OHdG of the patients were statistically much improved. This study demonstrated improvement in urinary symptoms, urinary QOL and oxidative stress, in LUTS resistant to anticholinergic agents and α-blockers. Further long-term studies will be needed not only in urinary symptoms, but also in effect as an anti-aging medicine.
ABSTRACT
We evaluated the effects of Hachimijiougan and its additional prescription in 11 cases of anticholinergic agent-resistant overactive bladder. The improvements in IPSS, QOL score, BII score and urinary 8-OHdG for the patients were statistically much improved. This study showed improvements of urinary symptoms and QOL in anticholinergic agent-resistant overactive bladder. Further long-term studies will be needed not only in urinary symptoms but also on effects as an anti-aging medicine.
ABSTRACT
Although the herbal preparation Kakkon-to is known to improve shoulder stiffness, there have been few studies attempting to elucidate the extent and mechanism of this effect. Kanebo Kakkon-to extract was administered orally to a group (n=19) of patients (pts) with shoulder stiffness (SS) at a dose of 2.5-7.5g/day, as well as to a group (n=9) of normal healthy subjects (NS). The effects and any side effects of Kakkon-to were then evaluated. The body surface temperature (BST) of the side of the neck was recorded from the Bide view position with a thermotracer before administration, after 30 minutes, after 60 minutes, after 90 minutes, and after 120 minutes. As for the general improvemant rates for this formula in the SS group, the rate of ‘remarkable improvement’ was 21.1%, ‘improvement’ 42.1%, and ‘slight improvement’ 15.8%. The overall utility rating, evaluated from the degree of improvement, was that the formula was considered ‘useful’ or better in 63.2% or the cases, and ‘slightly useful’ or better in 78.9% of the cases. Before administration of Kakkon-to, there was no significant difference between the BST of the SS group and that of the NS group, and no significant difference between the BST of improved pts in the SS group (n=12) and the BST of the Insufflciently improved pts in the SS group (n=7). The BST of the NS group 120 minutes after administration of Kakkon-to was higher than the pre-administration BST. There was no significant difference in the BST of the insufficiently improved pts of the SS group upon administration of Kakkon-to. The changes in the BST before and after administration of Kakkon-to were greater for the sufficiently improved SS group than for the insufficiently improved SS group or NS group. It was suspected that the effect of Kakkon-to on shoulder stiffness was due to improvement of blood circulation, as indicated by the higher BST.